NRTI/NtRTI

Drug

CrCl (ml/min)

Weight (kg)

Dose

didanosine (EC tabs)

≥60

≥60

400mg EC qd

30-59

200mg EC qd

10-29

125mg EC qd

<10

125mg EC qd

≥60

<60

250mg EC qd

30-59

125mg EC qd

10-29

125mg EC qd

<10

contraindicated

didanosine buffered powder for oral soln

≥60

≥60

250mg q 12 h

30-59

100mg q 12 h

10-29

167mg q 24 h

<10

100mg q 24 h

≥60

<60

167mg q 12 h

30-59

100mg q 12 h

10-29

100mg q 24 h

<10

100mg q 24 h

Emtricitabine

≥50

any

200mg qd

30-49

200mg q 48 h

15-29

200mg q 72 h

<15

200mg q 96h

Lamivudine

≥50

any

150mg bid or 300mg qd

30-49

150mg qd

15-29

150mg dose 1, then 100mg qd

5-14

150mg dose 1, then 50mg qd

<5

50mg dose 1, then 25mg qd

Stavudine

>50

≥60

40mg bid

26-50

20mg bid

10-25

20mg qd

>50

<60

30mg bid

26-50

15mg bid

10-25

15mg qd

Tenofovir

≥50

any

300mg qd

30-49

300mg q 48 h

10-29

300mg biw

Zalcitabine

10-40

any

0.75mg po bid

<10

0.75mg po qd

Zidovudine

<15

any

100mg po tid

Emtricitabine/tenofovir

≥50

any

1 tab po qd

30-49

1 tab po q 48 h

<30

use component drugs